Mentone Girls Secondary College is located on the corner of Balcombe and Charman Roads in Mentone, between Cheltenham and Mentone railway stations on the Frankston train line. Mentone is the closest train station and is walking distance from the College.
There are bus stops outside the school on Balcombe and Charman roads. School bus services are operated by:
- Moorabbin Transit – Ph: (03) 9585 0322
- Grendas Bus Service – Ph: (03) 9791 2988